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来自：43.159.*.*  QQ：	In July 1961 Searle finally started advertising and marketing Enovid 5 mg （5 mg noretynodrel and seventy five μg mestranol） to physicians as a contraceptive. In October 1951 G. D. Searle & Company refused Pincus‘ request to fund his hormonal contraceptive analysis but retained him as a guide and continued to provide chemical compounds to evaluate. In October 1951 Chemist Luis Miramontes working under the supervision of Carl Djerassi and the direction of George Rosenkranz at Syntex in Mexico City synthesized the primary oral contraceptive which was based mostly on extremely lively progestin norethisterone. Unable to curiosity his research sponsor Parke-Davis within the commercial potential of synthesizing progesterone from Mexican yams Marker left Penn State and in 1944 co-based Syntex with two companions in Mexico City. When he left Syntex a 12 months later the commerce of the barbasco yam had began and the interval of the heyday of the Mexican steroid trade had been started.
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